Circulating T Follicular Helper Cells in Dengue Virus immunity: Protection and Pathogenesis

Authors

  • José A. Collazo-Llera Ponce Health Sciences University, School of Medicine Author
  • Paola N. Flores-Pérez Ponce Health Sciences University, School of Medicine Author
  • Fabiola A. Rodríguez-Alvarado Ponce Health Sciences University, School of Medicine Author
  • Dr. Rivera-Amill Ponce Health Sciences University; Ponce Research Institute Author

DOI:

https://doi.org/10.71332/wc81nb17

Abstract

Dengue virus (DENV) infects ~400 million people annually and causes illness ranging from mild fever to life-threatening disease.

Effective immunity requires coordinated B-cell and T-cell activation.

Circulating T follicular helper cells (cTFH) support B-cell maturation, plasmablast expansion, and production of neutralizing antibodies (nAbs).

However, heightened cTFH activity may also contribute to antibody-dependent enhancement (ADE) and severe dengue. 

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Published

2025-12-22

Issue

Vol. 1 No. 2 (2025): Special Edition: Medical Student Summer Research Expo

Section

Articles

License

Copyright (c) 2025 José A. Collazo-Llera, Paola N. Flores-Pérez, Fabiola A. Rodríguez-Alvarado, Dr. Rivera-Amill (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright of their articles. All works are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited.